NMN is an antecedent of another molecule known as NAD+, which per research, can slow down the aging process. Living a longer and healthy life is possible with the increasing number of supplements boosting the NMN levels in the body and thus raising the NAD+ supply.
It is worth noting that NAD+ supplements can increase the longevity of living beings and reduce the chances of conditions like heart diseases, obesity, and other hosts of lifestyle diseases. The enzymes critical in repairing damaged DNA consume the essential enzymes, thus fueling our cells and getting our immune and metabolic systems stuck over. The main reason we usually experience health issues as we age is that the NAD+ levels decline naturally.
Keeping the levels of NAD+ high can help slow down the aging process, which is the responsibility of NMN. NMN acts as an NAD+ predecessor used by the body to produce more NAD+ levels.
Best NMN supplements dosage
The good thing about NMN is that it has negligible side effects, making this supplement safe for usage. The supplement does not yet have a universal recommended dosage, and different companies have their recommended dosages. Some brands, for instance, include NMN capsules bearing 125mg doses. In comparison, other brands like Prohealth offer NMN capsules with an easy dosage of 500mg and 1000 mg. Experts recommend a maximum daily dosage of 3.4mg NMN-C a pound. That is equivalent to 7.5mg of NMN-C a kilogram. That shows that the recommendations are dependent on an individual’s weight.
Many companies provide NMN in capsules and powder. A level scoop has 200mg-250mg NMN as their recommended two capsules dose has 250mg NMN. The doses of up to 1200 mg a day over six weeks of the supplementation of nicotinamide mononucleotide are safe for humans. There are three FDA-regulated clinical trials currently going through testing. You can access them via clinicaltrials.gov. Long-term evaluations are needed to determine whether the reagent’s capacity is safe for human consumption.
How much time does it take for NMN to work?
Research has demonstrated that long-term NMN administration can mitigate the age-related physiological decline. A twelve-month-long NMN administration is sufficiently tolerated without any deleterious administration. The long-term NMN administration also suppresses the weight gain associated with age while enhancing oxygen consumption, food intake, physical activity, and energy expedition. In addition to that, it was found to boost the plasma lipid profile and insulin sensitivity. NMN administration might also improve the bone density, eye function, and the composition of the myeloid-lymphoid.
The administration of NMN also prevents the changes in age-associated gene expression in a tissue-dependent manner. It also enhances the capability of mitochondrial respiration in the skeletal muscle. The pleiotropic effect of long-term administration of NMN creates a new avenue for the development of effective interventions for anti-aging through the use of major NAD+ intermediates like NMN.
A study has demonstrated that the administration of NMN of 500 mg/kg body weight increases NAD+ and tissue NMN levels within 15 minutes in the pancreas, liver, and the white adipose tissue (WAT) as the tested with the regular chow-fed wild mice. When lower doses that could potentially work with human beings were tested and added to drinking water, it confirmed that between 93 percent and 99 percent NMN was left or maintained intact at room temperature and in drinking water for approximately seven to ten days.
Interestingly results emerged after administering NMN at a dosage of 300 mg per kilogram of body weight to mice. The NMN administration was done through gavage. Then followed was the carrying out of measurements of plasma NMN levels and hepatic NAD+ over 30 minutes. Results showed that the plasma NMN levels increased sharply in two and a half minutes. It rose further from five to ten minutes, then reverted to the fifteen minutes original levels.
Another study demonstrates that NMN is absorbed quickly from the gut into the blood circulation in two to three minutes. Within the next 15 minutes, it is cleared from the blood circulation into tissues. It conducted an isotopic tracing experiment with C13-D-NMN, confirming the fast NMN absorption, including its immediate conversion to the NAD+ in tissues. That shows effective transporters directly taking up NMN into tissues and cells.
NMN supplement could be a game-changer since we all wish for a long and healthy life. It is even more, inviting given its other dozens of positive benefits expounded above. Imagine that the supplement improves your metabolism, which renders it more like a person who is ten to twenty years younger. Many studies are underway to determine the most effective dosages and modes of administration in humans. The lipid profile will also dramatically improve, making you feel more energetic, so you may want to look for some NMN supplements today.